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TAMPER RESISTANT DOSAGE FORM COMPRISING INORGANIC SALT
专利权人:
GRUNENTHAL GMBH
发明人:
Lutz BARNSCHEID
申请号:
US13781957
公开号:
US20130209557A1
申请日:
2013.03.01
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The invention relates to a pharmaceutical dosage form exhibiting a breaking strength of at least 500 N, said dosage form containing a pharmacologically active ingredient (A); an inorganic salt (B); and a polyalkylene oxide (C) having a weight average molecular weight of at least 200,000 g/mol, wherein the content of the polyalkylene oxide (C) is at least 20 wt.-%, based on the total weight of the dosage form; wherein the pharmacologically active ingredient (A) is present in a controlled-release matrix comprising the inorganic salt (B) and the polyalkylene oxide (C) and wherein, under in vitro conditions, the release profile of the pharmacologically active ingredient (A) from said matrix comprises at least a time interval during which the release follows zero order kinetics.
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