RNA interference is provided for inhibition of connective tissue growth factor mRNA expression in ocular disorders involving CTGF expression. Ocular disorders involving aberrant CTGF expression include glaucoma, macular degeneration, diabetic retinopathy, choroidal neovascularization, proliferative vitreoretinopathy and wound healing. Such disorders are treated by administering interfering RNAs of the present invention.係提供一種抑制結締組織生長因子mRNA表現之RNA干擾,用於治療與CTGF表現有關之眼睛病症。涉及CTGF異常表現之眼睛病症包括青光眼(glaucoma)、黃斑退化(macular degeneration)、糖尿病視網膜病變(diabetic retinopathy)、脈絡膜血管新生(choroidal neovascularization)、增生性玻璃體視網膜病變(proliferative vitreoretinopathy)與傷口癒合(wound healing)。此類病症係以本發明干擾性RNA治療。
