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IDENTIFICATION OF COMPOUNDS WHICH INHIBIT ATG8-ATG3 PROTEIN-PROTEIN INTERACTION AND THEIR USE AS ANTIPARASITICAL AGENTS
专利权人:
THE JOHNS HOPKINS UNIVERSITY
发明人:
Jürgen Bosch,Adelaide Ulrike P. Hain,Caren Freel Meyers,David Bartee
申请号:
US15306500
公开号:
US20170044150A1
申请日:
2015.04.27
申请国别(地区):
US
年份:
2017
代理人:
摘要:
The present invention provides compounds or a pharmaceutically acceptable salts, solvates, stereoisomers, or prodrugs thereof which can block the Atg8-Atg3 protein-protein interaction, which is associated with autophagy in apicomplexan organisms. Pharmaceutical compositions comprising these compounds and their use for the suppression and treatment of various parasitical diseases are also provided.
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