INHIBITEURS DE PYRIMIDINEDIAMINE KINASE

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专利权人:

RIGEL PHARMACEUTICALS; INC.

发明人:

SINGH, RAJINDER,ATUEGBU, ANDY,RAMPHAL, JOHN,LI, HUI,GELMAN, MARINA,CLOUGH, JEFFREY,VALDEZ, CARLOS,BHAMIDIPATI, SOMASEKHAR,THOTA, SAMBAIAH,MCMURTRIE, DARREN

申请号：

EP09837134

公开号：

EP2382210A4

申请日:

2009.12.29

申请国别(地区):

EP

年份:

2012

代理人:

摘要：

The present invention provides pyrimidinediamine compounds useful for inhibiting kinase activity, including the activity of polo-like kinase 1 (PLK1). Also provided are pharmaceutical compositions comprising these compounds and methods of treating diseases associated with kinase activity, in particular enhanced PLK1 catalytic activity, such as diseases associated with abnormal cell proliferation, including neoplastic disorders.

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