< Topic > At the time of this inventing, you discover the percutaneous absorption accelerator which possesses the percutaneous absorption promotion operation of the carbon dioxide which is superior you designate that the skin of carbon dioxide and the carbon dioxide foaming Characteristic skin external use medicine which raises the absorption effect to the mucous membrane are offered by blendinging to solid condition, granulation condition, fine grain condition or the powdered carbon dioxide foaming Characteristic skin external use medicine, as topic. Solutions Reacting with the acidic material and the aforementioned acidic material, it is possible to raise the permeability to the skin of carbon dioxide, blendinging by in the carbon dioxide generation material and contain the percutaneous absorption accelerator of carbon dioxide solid condition, granulation condition, fine grain condition or the powdered carbon dioxide foaming Characteristic skin external use medicine which generate carbon dioxide, the liquefied oily fluid as the skin absorption accelerator of carbon dioxide. < Choice figure >It is not【課題】 本発明においては、優れた炭酸ガスの経皮吸収促進作用を有する経皮吸収促進剤を見出し、固形状、顆粒状、細粒状又は粉末状の炭酸ガス発泡性皮膚外用剤に配合することにより、炭酸ガスの皮膚や粘膜への吸収効果を高めた炭酸ガス発泡性皮膚外用剤を提供することを課題とする。【解決手段】 酸性物質、前記酸性物質と反応して炭酸ガスを発生する炭酸ガス発生物質及び炭酸ガスの経皮吸収促進剤を含有する固形状、顆粒状、細粒状又は粉末状の炭酸ガス発泡性皮膚外用剤において、液状油剤を炭酸ガスの皮膚吸収促進剤として配合することにより、炭酸ガスの皮膚への透過性を高めることができる。【選択図】なし
