Mutated truncated von Willebrand Factor

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专利权人:

CSL Behring Recombinant Facility AG

发明人:

Andrews, Arna,Panousis, Con,Emmrich, Kerstin,Wilson, Michael,Dower, Steve,Hardy, Matthew,Hartman, Dallas

申请号：

AU2017204955

公开号：

AU2017204955A1

申请日:

2017.01.06

申请国别(地区):

AU

年份:

2018

代理人:

摘要：

The present invention provides a modified polypeptide which binds Factor VIII. The polypeptide comprises truncated von Willebrand Factor (VWF) which comprises a sequence as shown in SEQ ID NO:3 or a fragment thereof or a sequence 90% identical thereto, wherein the truncated VWF comprises at least one modification in comparison to SEQ ID NO: 3 in at least one position selected from the group consisting of SI, S3, LI 8, V42, S43, K149, N248, S279, V320, T325, Q395 and K418.

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