Susan Zolla-Pazner,Miroslaw K. Gorny,Timothy J. Cardozo,Xiang-peng Kong,Ruben Abagyan,Maxim Totrov,Shan Lu,Abraham Pinter
申请号：
US12195318
公开号：
US08961987B2
申请日:
2008.08.20
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Insertion of HIV-1 V3 loop peptides from the viral glycoprotein gp120 into selected, immunogenic scaffold proteins results in a recombinant polypeptide that is a potent V3 immunogen. V3 immunogens include natural and consensus V3 sequences and cyclic and reverse peptides. Preferred scaffold proteins are Cholera Toxin subunit B and homologues thereof including closely related E. coli enterotoxins. Such immunogenic polypeptides induce broadly reactive anti-gp120 antibodies specific for V3 epitopes that can neutralize heterologous HIV-1 subtypes and strains. These polypeptide, methods for preparing them, and methods for inducing anti-gp120 (V3-specific) antibody) responses using them are disclosed.
