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METHODS OF TREATING CANCER USING ANTI-OX40 ANTIBODIES AND PD-1 AXIS BINDING ANTAGONISTS
专利权人:
发明人:
Ina P. RHEE,Jeong KIM,Mahrukh HUSENI,Eric STEFANICH,Siddharth SUKUMARAN,Chi-Chung LI
申请号:
US15842380
公开号:
US20180256711A1
申请日:
2017.12.14
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The invention provides methods of treating or delaying progression of cancer in an individual comprising administering to the individual an anti-human OX40 agonist antibody and an anti-PDL1 antibody. In some embodiments, the anti-human OX40 agonist antibody is administered in a dose selected from about 0.8 mg, about 3.2 mg, about 12 mg, about 40 mg, about 80 mg, about 130 mg, about 160 mg, about 300 mg, about 320 mg, about 400 mg, about 600 mg, and about 1200 mg, and the anti-PDL1 antibody is administered at a dose of about 800 mg or about 1200 mg.
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