HYDROXAMATE DERIVATIVES BEARING AMIDE-LACTAMS AS POTENT HDAC INHIBITORS AND THEIR USES AS MEDICAMENTS

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专利权人:

SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S. P. A.

发明人:

GIANNINI, GIUSEPPE,珍尼尼 葛斯佩,珍尼尼 葛斯佩,VESCI, LOREDANA,维希 罗瑞达纳,維希 羅瑞達納,BATTISTUZZI, GIANFRANCO,巴提斯吐济 詹法兰克,巴提斯吐濟 詹法蘭克,VIGNOLA, DAVIDE,维格诺拉 大卫,維格諾拉 大衛,TADDEI, MAURIZIO,泰迪 毛里奇欧,泰迪 毛里奇歐

申请号：

TW103104062

公开号：

TW201443016A

申请日:

2014.02.07

申请国别(地区):

TW

年份:

2014

代理人:

摘要：

The present invention relates to novel amide compounds of Formula (I), and their use as anti-tumoral and pro-apoptotic agents.The invention includes the use of such compounds in medicine, in relation to cancer disease as well as other diseases where an inhibition of HDAC is responsive, and the pharmaceutical com-position containing such compounds.本發明係關於如通式(I)之一種新的醯胺化合物及其作為抗腫瘤及促細胞凋亡因子。本發明包括上述化合物在癌症疾病及其他與組蛋白脫乙醯基酶抑制相關的疾病之醫藥用途,以及含有上述化合物之藥物組合物。

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/