Systems and methods of detecting a portion within tissue that has a variation of local magnetic susceptibility using an MRI device, including: transmitting a first spin-echo pulse sequence to the tissue, wherein the first spin-echo pulse sequence includes a first number of refocus pulses and a first TE value； transmitting a second spin-echo pulse sequence to the tissue, wherein the second spin-echo pulse sequence includes a second number of refocus pulses and a second TE value； obtaining a first image and a second image； determining one or more locations within the second image having a signal intensity that is different than the signal intensity of the same one or more locations within the first image； and identifying a portion of tissue that has a varied local magnetic susceptibility based on the determined one or more locations within the second image.
