A combination comprising: (i) N- {3- [3-cyclopropyl-5- (2-fluoro-4-iodo-phenylamino) 6,8-dimethyl； -2,4,7-trioxo-3,4, 6,7-tetrahydro-2H-pyrido [4,3- d] pyrimidin-1-yl] phenyl} acetamide (a compound of structure (I)): ** Formula ** or a pharmaceutically acceptable salt or solvate thereof； and (ii) everolimus.Una combinación que comprende: (i) N-{3-[3-ciclopropil-5-(2-fluoro-4-yodo-fenilamino)6,8-dimetil；-2,4,7-trioxo-3,4,6,7-tetrahidro-2H-pirido[ 4,3- d]pirimidin-1-il]fenil}acetamida (un compuesto de estructura (I)):**Fórmula** o una sal o solvato farmacéuticamente aceptable del mismo； y (ii) everolimus.
