An implant comprising a multi-directional locking mechanism that allows a bone fixation device, such as a screw, to be rigidly affixed to the implant in a plurality of angles relative to the implant. The implant can be a bone plate, a component of a joint prosthesis or the like. The locking mechanism comprises a passage hole in the implant for passage of a bone fixation device therethrough. One or more beam members are arranged adjacent the passage hole and a space is associated with each beam member. Each space allows the associated beam member to move into or about the space upon axial and/or radial deformation of the beam member caused by fastening the bone fixation device to a bone. The beam members and associated elements of the locking mechanism are sufficiently thin to permit axial and/or radial deformation. And said deformation causes the fixation device to be locked in place relative to the implant.
