WEN, BEN,BOITANO, ANTHONY E.,BURGER, MATTHEW,CELLITTI, SUSAN E.,COOKE, MICHAEL P.,FINNER, CATRIN,GEIERSTANGER, BERNHARD HUBERT,JIN, YUNHO,LEE-HOEFLICH, SI TUEN,PHAM, HONGNGOC THI,SCHLEYER, SIEW HO,TIS
申请号：
CA3045592
公开号：
CA3045592A1
申请日:
2017.12.19
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention provides antibody drug conjugates, wherein an antibody or antibody fragment that specifically binds to human cKIT is linked to a drug moiety, optionally through a linker. The present invention further provides pharmaceutical compositions comprising the antibody drug conjugates； and methods of making and using such pharmaceutical compositions for ablating hematopoietic stem cells in a patient in need thereof.
