Disclosed herein are novel compositions for treating or preventing upper GI tract disorders and protecting stratified squamous epithelium against injury by a noxious substance. The pharmaceutical composition comprises at least one bile acid sequestrant, alone or in combination with at least one proton pump inhibitor, and optionally one or more agent chosen from antacids, histamine H2-receptor antagonists, -aminobutyricacid-b (GABA-B) agonists,, prodrugs of GABA-B agonists, and protease inhibitors.Mevcut başvuru genel olarak kolesevelam, kolesevelam hidroklorür, kolestipol, sevelamer veya bunların bir kombinasyonunun yemek borusu rahatsızlıklarının tedavisinde kullanılması ile ilgilidir.
