ЙОВИНЕ Алехандро (CH),СКВАЙРС Мэттью (CH),РЕДДИК Кэтерин (US),ЧЖАН Юн (US)
申请号：
RU2014135436
公开号：
RU2014135436A
申请日:
2013.01.30
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
A pharmaceutical combination comprising: (a) an RTK inhibitor compound, a compound of the formula I, a tautomer of the compound, a salt of the compound, a tautomer salt, or a mixture thereof, wherein the compound of the formula I is represented by the following formula: in which R, R, R and R can be identical or different and are independently selected from the group consisting of H, Cl, Br, F, I, -OR groups, -NRR groups, substituted or unsubstituted primary, secondary or tertiary alkyl groups, substituted or unsubstituted aryl groups, substituted or unsubstituted alkenyl groups , replaced substituted or unsubstituted heterocyclyl groups, or substituted or unsubstituted heterocyclylalkyl groups R, R, R and R may be the same or different and are independently selected from the group consisting of H, Cl, Br, F, I, -OR groups, -NRR, -SR groups, substituted or unsubstituted primary, secondary or tertiary alkyl groups, substituted or unsubstituted aryl groups, substituted or unsubstituted alkenyl groups, substituted or unsubstituted alkynyl groups, substituted or unsubstituted heterocyclyl groups, substituted or unsubstituted heterocyclylalkyl groups, substituted or unsubstituted alkoxyalkyl groups, substituted or unsubstituted aryloxyalkyl groups or substituted or unsubstituted heterocyclyloxyalkyl groups R and R may be the same and whether different and independently selected from the group consisting of substituted or unsubstituted alkyl groups, substituted or unsubstituted aryl groups, substituted or unsubstituted heterocyclyl groups, substituted or unsubstituted heterocyclylalkyl groups, substituted or unsubstituted alkoxy1. Фармацевтическая комбинация, включающая:(a) соединение-ингибитор RTK, представляющее собой соединение формулы I, таутомер соединения, соль соединения, соль таутомера или их смесь, где соединение формулы I описывается следующей формулой:в которой R1, R2, R3 и R4 могут быть одинаковыми или разными и независимо выбраны из группы, включающей H, Cl,
