ZHANG JING,ZHANG ZHUMING,SMITH MARK,TALAMAS FRANCISCO XAVIER
申请号：
NZ62584412
公开号：
NZ625844A
申请日:
2012.12.17
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
Provided are 4&rsquo；-azido, 3&rsquo；-fluoro substituted nucleoside phosphoramidate derivative compounds of the general formula I, where the variables are as defined in the specification. Examples of the compounds include S)-2-{ [(2R,3S,4S,SR)-2-Azido-S-(2,4-dioxo-3 ,4-dihydro-2H-pyrimidin-1-yl)-3-fluoro-4-hydroxy-tetrahydro-furan-2-ylmethoxy]-phenoxy-phosphorylamino} -propionic acid isopropyl ester and (S)-2-[[(2R,3S,4S,5R)-5-(4-Amino-2-oxo-2H-pyrimidin-1-yl)-2-azido-3-fluoro-4-hydroxy-tetrahydro-furan-2-1-6ylmethoxy]-(naphthalen-1-yloxy)-phosphorylamino]-propionic acid ethyl ester. The compounds are inhibitors of hepatitis C virus (HCV) RNA replication.
