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NEW PEPTID AND ITS USE
专利权人:
ЭНСОЛТЕК КО.; ЛТД. (KR)
发明人:
КИМ Хэ Джин (KR),МУН Ын Чон (KR),КИМ Ян Сон (KR),КВОН Ён Чун (KR)
申请号:
RU2012108179/10
公开号:
RU2012108179A
申请日:
2010.02.12
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
1. A peptide containing the amino acid sequence of SEQ ID NO: 1.2. The peptide according to claim 1, where the peptide is in the form of its variant and retains its main activity. The peptide according to claim 1, wherein the peptide is in the form of its pharmaceutically acceptable salt. The peptide according to any one of claims 1 to 3, where the peptide or its variant has the general formula (I) L-X-VV-X-L-X, (I) where X is Q or N; X is Y, F, or W; X is H, K or R; L is leucine; Q is glutamine; N represents asparagine; V is valine; Y represents tyrosine; F is phenylalanine; W represents tryptophan; H represents histidine; K is lysine; and R is arginine. 5. A composition for treating and preventing osteochondrosis, a composition comprising a peptide according to any one of claims 1 to 4. A composition for treating diseases selected from the group comprising: body organ fibrosis, cancer, glomerulosclerosis, a composition comprising a peptide according to any one of claims 1 to 4.7. The composition of claim 6, wherein the treatment is performed by inhibiting TGF-beta1 signaling. The use of the peptide according to any one of claims 1 to 4 for the manufacture of a medicament for the treatment and prevention of osteochondrosis. The use of the peptide according to any one of claims 1 to 4 for the manufacture of a medicament for the treatment of diseases selected from the group comprising: body organ fibrosis, cancer, glomerulosclerosis. 10. A method for the treatment and prevention of osteochondrosis, a method in which a peptide according to any one of claims 1 to 4.11 is administered to a subject. A method for treating diseases selected from the group comprising: body organ fibrosis, cancer, glomerulosclerosis, a method in which a peptide is administered to a subject according to any1. Пептид, содержащий аминокислотную последовательность SEQ ID NO: 1.2. Пептид по п.1, где пептид находится в форме своего варианта и сохраняет свою главную активность.3. Пептид по п.1, где
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