Lubris LLC;Rhode Island Hospital, A Life Span Partner
发明人:
Jay, Gregory D.,Sullivan, Benjamin D.,Schmidt, Tannin Avery,Elsaid, Khaled,Truitt, Edward R.,Krawetz, Roman,Szmydynger-Chodobska, Joanna,Chodobska, Adam,Fareed, Jawed
申请号：
AU2016211694
公开号：
AU2016211694A1
申请日:
2016.01.26
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
Disclosed herein are methods of using PRG4 glycoprotein, also known as lubricin, to reduce, inhibit, or down-regulate pro-inflammatory pathways in patients at risk of or suffering from an inflammatory response or allergy symptom through CD44 antagonization, regulating pro-inflammatory cytokine production, inhibiting NF-κΒ translocation and/or facilitating removal of inflammation-inducing cellular or matrix debris or allergens.
