Chemical preconditioning process for cell material to obtain chemical epigenetic reprogramming and pluripotency expression of stem and multipotent elements of non-embryonic origin, such as pericytes and/or mesenchymal stem cells, and/or adult somatic cells. The process includes the step of subjecting a non-expanded tissue derivative having the stem and multipotent elements, and/or of subjecting non-embryonic stem cells and/or non-embryonic somatic cells, obtained from a tissue sample or from the derivative, to a mixing with hyaluronic acid esterified with butyric and retinoic acids (HBR).
