BERTRAM, Ulrike,REINHOLD, Ulrich,GROßE, Christian,HARTMANN, Carmen
申请号：
AU2020233614
公开号：
AU2020233614A1
申请日:
2020.09.14
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
#$%^&*AU2020233614A120201008.pdf#####Abstract: Dosage Form Providing Prolonged Release of Tapentadol Phosphoric Acid Salt The invention relates to a pharmaceutical dosage form providing prolonged release of Tapentadol, wherein Tapentadol is present in form of a salt with phosphoric acid (orthophosphoric acid), preferably as dihydrogenphosphate salt. The dosage form according to the invention provides improved prolonged release properties, is particularly resistant against ethanol induced dose dumping, and beyond such resistance provides additional safety features with regard to concomitant use of ethanol, e.g. alcoholic beverages.
