Mark Oldham,Justus Adamson,Paul Yoon,Harold Walder,Frederic A. Bourke, JR.,Zakaryae Fathi,Wayne F. Beyer
申请号：
US15819130
公开号：
US20180154178A1
申请日:
2017.11.21
申请国别(地区):
US
年份:
2018
代理人:
摘要：
A phosphor-containing drug activator activatable from a Monte Carlo derived x-ray exposure for treatment of a diseased site. The activator includes an admixture or suspension of one or more phosphors capable of emitting ultraviolet and visible light upon interaction with x-rays, wherein a distribution of the phosphors in the diseased target site is based on a Monte Carlo derived x-ray dose. A system for treating a disease in a subject in need thereof, includes the drug activator and a photoactivatable drug, one or more devices which infuse the photoactivatable drug and the activator including the pharmaceutically acceptable carrier into a diseased site in the subject and an x-ray source which is controlled to deliver the Monte Carlo derived x-ray exposure to the subject for production of ultraviolet and visible light inside the subject to activate the photoactivatable drug.
