Disclosed are biocompatible, biodegradable, implantable devices for the controlled release of bioactive molecules. In particular embodiments, nanotechnology-based tunable implants are disclosed for 1) localized delivery of analgesics to treat postoperative pain； 2) sustained delivery of growth factors to promote vascularization； and 3) directing tissue regeneration, including the self-direction of autologous stem cells for organ remodeling.
