Patent Summary for: "Topical compositions comprising fipronil and permethrin and methods of use". The subject matter described herein relates to highly effective stable topical formulations comprising permethrin, fipronil and a solvent system that is sufficient to solubilize these two active ingredients and limit the degradation of fipronil in its sulfone, and their uses in topical animal and animal applications. environment. Useful formulations comprise from about 30% to about 55% (w / w) permethrin and about 2 to 15% (w / w) fipronil and a solvent system comprising n-methyl pyrrolidone and a glycol, ether glycol ester, glycol ester, fatty acid ester or neutral oil, wherein n-methyl pyrrolidone and glycol, glycol ether, glycol ester, fatty acid ester or neutral oil are present in a weight: weight ratio of about 1: 2.0 to about 1: 3.5 of glycol, glycol ether, glycol ester, fatty acid ester or n-methyl pyrrolidone neutral oil. These two active agents, when combined in the amounts described, have been found to have unexpected increased repellent activity against stable fly. however, it is the formulations described herein that confer stability and solvency that maintain synergistic concentrations upon application to an animal.resumo da patente de invenção para: "composições tópicas compreendendo fipronil e permetrina e métodos de uso". a matéria descrita aqui se refere a formulações tópicas estáveis altamente eficazes compreendendo permetrina, fipronil e um sistema de solvente que é suficiente para solubilizar estes dois ingredientes ativos e limitar a degradação de fipronil em sua sulfona, e seus usos em aplicações tópicas em animais e ao meio ambiente. formulações úteis compreendem de cerca de 30% a cerca de 55% (p/p) de permetrina e cerca de 2 a 15% (p/p) de fipronil e um sistema de solvente que compreende n-metil pirrolidona e um glicol, éter de glicol, éster de glicol, éster de ácido graxo ou óleo neutro, em que a n-metil-pirrolidona e glicol, éter de glicol, ést
