This invention relates to biopharmaceutical technology, specifically to the application of 3,3'-Diindolylmethane, indole-3-carbinol, and derivatives thereof in the preparation of drugs for treating such hepatic diseases as viral hepatitis, alcoholic hepatitis, drug-induced hepatitis, fatty liver, hepatic fibrosis and hepatic cirrhosis. The said indole-3-carbinol, diindolylmethane and derivatives thereof can effectively protect the human body from the damage resulting from ROS by inhibiting ROS-induced activation of hepatic stellate cells and correlated expression of collagen, which consequently ameliorates degree of hepatic fibrosis. Therefore they can be used in treatment of diseases related to hepatic fibrosis. As is verified in the animal models of hepatic fibrosis, the said indole-3-carbinol, diindolylmethane and derivatives thereof present excellent therapeutic effect and positive application prospect.ウイルス性肝炎、アルコール性肝炎、薬物誘発性肝炎、脂肪肝、肝線維化又は肝硬変を治療する薬物の製造における、３，３’－ジインドリルメタン及びインドール－３－メタノール並びにそれらの誘導体の応用。
