The invention describes binding molecules of anti-CD3 epsilon antibodies, anti-cd123 antibodies and antibodies similar to the combination of CD3 and CD123, which combine CD3 cells with CD123 tumor cells, and can connect t primary cells and lisar tumor target cells.La invención describe anticuerpos anti-CD3 epsilon, anticuerpos anti-CD123 y moléculas de unión similar a anticuerpo que se unen a CD3 y CD123 que unen células CD3 y a células tumorales CD123 capaces de conectar células T primarias y lisar células diana tumorales.