A generally lossless compression system suitable for compression of data in a real-time, remote monitoring application is disclosed. In one embodiment, the real-time monitoring application is subject to a fixed-delay transmission constraint. In one implementation, a specific set partitioning method (e.g., binary tree partitioning) is employed on blocks of data that are wavelet transformed in a reversible manner so that encoded blocks may be transmitted losslessly or truncated and transmitted with some loss.