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СПОСОБ КОЛИЧЕСТВЕННОЙ ОЦЕНКИ ФУНКЦИОНАЛЬНОГО СОСТОЯНИЯ ВАЖНЕЙШИХ СИСТЕМ ОРГАНИЗМА
专利权人:
Бондырев Юрий Анатольевич
发明人:
Бондырев Юрий Анатольевич
申请号:
RU2014132529
公开号:
RU2014132529A
申请日:
2014.08.06
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. A method for quantitative assessment of the functional state of the bodys systems, in which the process of exploring the development of a sterile inflammation of the tissue caused by ultraviolet (UV) radiation (UVR) of different spectral composition, intensity and dose, as measured by the degree of severity of flushing (erythema) UV irradiated portion, wherein in that for the measurement of apoptosis system activity induced by UV radiation is measured the slope (k) and the point of intersection with the abscissa (the maximum NeEritemogennaya dose - VLED) dose dependence of the degree of redness UV irradiated portion of the test body tissue at different (up to 48 h after UV irradiation) points vremeni.2. The method of claim. 1, characterized in that, in order to investigate the activity of agents which modulate apoptosis, and comparing the values ​​k VLED in systemic and / or local apoptosis-modulating activity of pharmacological effects and without them for rapid and delayed UVB eritemy.3 . The method of claim. 1, characterized in that, in order to study the function of the immune system, comparing the kinetics of redness caused by UV-C (250-280 nm) and UV-B (280-320 nm) in systemic exposure and / or local pharmacologic effects and without nih.4. The method of claim. 1, characterized in that, in order to study the intracellular repair systems, comparing the degree of redness of the same doses of ultraviolet radiation produced by UV irradiation intensivnosti.5 different. The method of claim. 1, characterized in that the trigger threshold for the measurement of apoptosis induced by ultraviolet irradiation, UV-B kinetics erythema produced using mikrofraktsionnogo irradiation was examined in comparison with erythema kinetics obtained with n1. Способ количественной оценки функционального состояния систем организма, при котором исследуют процесс развития стерильного воспаления участка ткани, вызванного ультрафиолетовым (УФ) излучением (УФИ) различного спектрального сос
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