A synergistic combined treatment for plant, insect, and rodent-vermin pests system and method addressing the combination problem of overproliferating plants harboring blood-feeding insects, rodents, and other vermin animals, providing a pest-control combination solution comprising a stabilized glyphosate solution, a sequestered manganese solution, a stabilized progestin solution, and a carrier solution, applied as a spray, where, after application, the various components and the breakdown products of the various components increase the efficacy and promote the safe breakdown in the environment of the other components.