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Nitrogenated AROMATIC 6-membered RINGDERIVAT, AND THIS pharmaceutical composition comprising
专利权人:
DAIICHI SANKYO COMPANY; LIMITED
发明人:
TAKEMOTO, NAOHIRO,MURAYAMA, NORIHITO,MURATA, KENJI,YAMADA, CHIKAOMI
申请号:
DK08764246
公开号:
DK2151439T3
申请日:
2008.04.25
申请国别(地区):
DK
年份:
2014
代理人:
摘要:
Provided is a compound that has the ability to promote axonal outgrowth in combination with the ability to promote angiogenesis and can therefore be used to reduce central nerve injuries such as head injury and spinal cord injury, cerebral infarction, ischemic heart diseases such as myocardial infarction and organic angina, peripheral arterial occlusive diseases such as critical limb ischemia, or after-effects of these diseases. Specifically, the compound is represented by the following formula (I): in which Nx group is preferably a 6-membered aromatic ring containing two nitrogen atoms; R 0 , R 1 and R 2 are each independently a hydrogen atom, an alkyl group, an amino group or the like; E is an oxygen atom or an -NR 8 group (wherein R 8 is an alkyl group or the like); n is an integer of 0 to 5; X and Y are each a connecting bond, a cycloalkyl group, -CO- or the like; and Q is a hydrogen atom or a phenyl group.
来源网站:
中国工程科技知识中心
来源网址:
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