A new and distinct cultivar of Poinsettia plant named ‘PER2109’, characterized by its compact, uniform, upright and mounded plant habit moderately vigorous growth habit freely and upright branching habit dark green-colored leaves mid-season flowering response under natural season conditions, plants flower in late November in Southern California large inflorescences with dusty pink-colored flower bracts covered with light red-colored random speckles and splotches and good post-production longevity.