ALETHIA BIOTHERAPEUTICS INC.;NATIONAL RESEARCH COUNCIL OF CANADA
发明人:
Gilles Bernard TREMBLAY,Mario FILION,Traian SULEA
申请号：
US14311840
公开号：
US20140302020A1
申请日:
2014.06.23
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Novel antibodies and antigen binding fragments that specifically bind to clusterin are described. In some embodiments, the antibodies block the biological activity of clusterin and are useful in composition in certain cancers, more particularly in cancers, such as endometrial carcinoma, breast carcinoma, hepatocellular carcinoma, prostate carcinoma, a renal cell carcinoma, ovarian carcinoma, pancreatic carcinoma, and colorectal carcinoma. The invention also relates to cells expressing the humanized or hybrid antibodies. Additionally, methods of detecting and treating cancer using the antibodies and fragments are also disclosed.
