University of Massachusetts;Dana-Farber Cancer Institute, Inc.
发明人:
Jason J. Marineau,James E. Bradner,Wei Zhang,Jun Qi,Michael R. McKeown,Harry Hongning Fu,Shuai Liu
申请号：
US14907339
公开号：
US09975896B2
申请日:
2014.07.25
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention provides novel compounds of any one of Formulae (I) to (IV), and pharmaceutically compositions thereof. Compounds of any one of Formulae (I) to (IV) are believed to be inhibitors of bromodomain-containing proteins (e.g., bromo and extra terminal proteins (BETs)). Also provided are methods, uses, and kits using the inventive compounds and pharmaceutical compositions for inhibiting the activity of the bromodomain-containing proteins and for treating and/or preventing in a subject in need thereof diseases associated with bromodomain-containing proteins, such as proliferative diseases.
