< Topic >Eyeground disease, especially diabetes retina symptom or prevention of age increase yellow spot denaturation or offer of medicine for remedying. Solutions(S) - (-) the 1 (4 fluoro 5 isoquinoline sulfonyl) the preventive of the eyeground disease which designates 2 methyl 1,4 homo- piperazine or that salt or those solvent dishes dressed with sauce as the active ingredient or remedy medicine. < Choice figure >It is not【課題】眼底疾患、特に糖尿病網膜症又は加齢黄斑変性の予防又は治療のための薬剤の提供。【解決手段】(S)-(-)-1-(4-フルオロ-5-イソキノリンスルホニル)-2-メチル-1,4-ホモピペラジン若しくはその塩又はそれらの溶媒和物を有効成分とする眼底疾患の予防又は治療剤。【選択図】なし