HOGER THOMAS U,HOSSE RALF,MOESSNER EKKEHARD,UMANA PABLO
申请号：
IN1901/CHENP/2012
公开号：
IN2012CN01901A
申请日:
2012.02.29
申请国别(地区):
IN
年份:
2013
代理人:
摘要：
The present invention relates to antigen binding molecules (ABMs). In particular embodiments the present invention relates to recombinant monoclonal antibodies including chimeric primatized or humanized antibodies or variants thereof specific for cell surface or membrane bound human CEA. In addition the present invention relates to nucleic acid molecules encoding such ABMs and vectors and host cells comprising such nucleic acid molecules. The invention further relates to methods for producing the ABMs of the invention and to methods of using these ABMs in treatment of disease. In addition the present invention relates to ABMs with modified glycosylation having improved therapeutic properties including antibodies with increased Fc receptor binding and increased effector function.
