Composition comprising the purified fraction isolated from bee venom for preventing and treating a joint disease comprising a cervical and lumbar disc or inflammatory disease and manufacturing method thereof
The present invention relates to a composition for the prevention and treatment of joint diseases or inflammatory diseases, which comprises the bee venom purified product as an active ingredient, and a process for producing the same, and more particularly, to a process for producing a pore size capable of filtering a substance having a molecular weight of 7 to 10 kDa size of the bee venom, the bee venom purified by the cellulose membrane was found to effectively remove allergen-inducing substances and bacterial endotoxin in bee venom, and exhibited cell proliferation inhibition and anti-inflammatory effect in macrophages as well as excellent clinical effects By confirming, the composition of the present invention can be usefully used as a composition for the prevention and treatment of joint diseases or inflammatory diseases.본 발명의 봉독 정제물을 유효성분으로 포함하는 관절 질환 또는 염증성 질환 예방 및 치료를 위한 조성물 및 이의 제조방법에 관한 것으로, 구체적으로 7 내지 10 kDa의 분자량의 물질을 여과할 수 있는 공극 크기(pore size)를 갖는 셀룰로스(cellulose) 막으로 여과시킨 봉독 정제물은 봉독 내 알러지 유발 물질 및 세균 내 독소가 효과적으로 제거됨을 확인하였고, 대식세포에서 세포증식 억제 및 항염증 효과를 나타낼 뿐만 아니라 우수한 임상효과를 확인함으로써, 본발명의 조성물은 관절 질환 또는 염증성 질환의 예방 및 치료용 조성물로 유용하게 사용될 수 있다.
