Chi-Huey Wong,Chung-Yi Wu,Sarah K. C. Cheung,Po-Kai Chuang,Tsui-Ling Hsu
申请号：
US15005930
公开号：
US10495645B2
申请日:
2016.01.25
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present disclosure relates to methods and compositions which can modulate the globoseries glycosphingolipid synthesis. Particularly, the present disclosure is directed to glycoenzyme inhibitor compound and compositions and methods of use thereof that can modulate the synthesis of globoseries glycosphingolipid SSEA-3/SSEA-4/GloboH in the biosynthetic pathway； particularly, the glycoenzyme inhibitors target the alpha-4GalT； beta-4GalNAcT-I； or beta-3GalT-V enzymes in the globoseries synthetic pathway. Additionally, the present disclosure is also directed to vaccines, antibodies, and/or immunogenic conjugate compositions targeting the SSEA-3/SSEA-4/GLOBO H associated epitopes (natural and modified) which elicit antibodies and/or binding fragment production useful for modulating the globoseries glycosphingolipid synthesis. Moreover, the present disclosure is also directed to the method of using the compositions described herein for the treatment or detection of hyperproliferative diseases and/or conditions. Furthermore, the instant disclosure also relates to cancer stem cell biomarkers for disgnostic and therapeutic uses.
