The antibodies described in this note were combined with TNFa and showed binding with modified FcRn. The antibody has good bactericidal function and / or pharmacy characteristics. Nucleic acid, drug composition and treatment.La presente descripción se refiere a anticuerpos que se unen a TNFa y exhiben unión a FcRn modificada. Los anticuerpos tienen buenas funciones efectoras y/o propiedades farmacocinéticas. Ácido nucleico, composición farmacéutica y método de tratamiento.