Agnes M. Rimando,Dennis R. Feller,Wallace H. Yokoyama
申请号：
US13363959
公开号：
US08252845B1
申请日:
2012.02.01
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Resveratrol has been reported to have hypolipidemic properties. We investigated whether resveratrol and its analogs: pterostilbene, piceatannol and resveratrol trimethyl ether, would activate the peroxisome proliferator-activated receptor alpha (PPARα) isoform. This nuclear receptor is proposed to mediate the activity of lipid-lowering drugs such as the fibrates. The four stilbenes and ciprofibrate (positive control) were evaluated for the activation of endogenous PPARα in H4IIEC3 cells transfected with a luciferase gene reporter construct. Pterostilbene demonstrated the highest induction of PPARα the maximal response to pterostilbene was similar to that obtained with the hypolipidemic drug, ciprofibrate.
