Condensed pyrrole as an IP receptor agonist for the treatment of pulmonary arterial hypertension (PAH) and related disorders

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专利权人:

ノバルティス アーゲー

发明人:

ルブラン，キャサリン,アドコック，クレア,ルブラン,キャサリン,アドコック,クレア

申请号：

JP2014551714

公开号：

JP6073923B2

申请日:

2013.01.11

申请国别(地区):

JP

年份:

2017

代理人:

摘要：

The present invention provides compounds of formula (Ia) and (Ib) which activate the IP receptor, processes for preparing them, pharmaceutical compositions comprising said compounds and uses thereof. Activating the IP receptor signaling pathway is useful to treat many forms of PAH, pulmonary fibrosis and exert beneficial effects in fibrotic conditions of various organs in animal models and in patients.

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中国工程科技知识中心

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http://www.ckcest.cn/home/