A method of treating a condition related to iron deficiency. The method includes steps of identifying a patient having a condition related to iron deficiency and administering an effective amount of biocompatible iron oxide nanoparticles to the patient. The biocompatible iron oxide nanoparticles each contains an iron oxide core that is covered by one or more biocompatible polymers, each of which has a polyethylene glycol group, a silane group, and a linker linking, via a covalent bond, the polyethylene glycol group and the silane group.一種治療一與鐵缺乏症相關之病況的方法。該方法包括鑑別一具有一與鐵缺乏症相關之病況的病患,以及將一有效量之生物相容性氧化鐵奈米粒子投藥給該病患。該等生物相容性氧化鐵奈米粒子各自包含一氧化鐵核心,其係被一或多個生物相容性聚合物覆蓋,該等生物相容性聚合物各自具有一聚乙二醇基團、一矽烷基團以及一經由共價鍵連接該聚乙二醇基團及該矽烷基團的連接基。