FORESEE PHARMACEUTICALS CO. LTD.;ANDREW J. GUARINO;YUHUA LI
发明人:
申请号：
IL25170317
公开号：
IL251703D0
申请日:
2017.04.12
申请国别(地区):
IL
年份:
2017
代理人:
摘要：
The present invention provides an injectable composition for controlled release drug delivery and the process of making the same, where the composition comprises: a lactate-based polymer having a weight average molecular weight between 5,000 and 50,000 dalton, an acid number of less than 3 mgKOH/g and the content of residual lactide monomers in the lactate-based polymer of less than about 0.3% by weight； a pharmaceutically acceptable organic solvent； and a bioactive substance or a salt thereof that contains an amino acid serine in the molecular structure that is capable of reacting with lactide monomer to form a conjugate； and where the composition reduces the formation of the conjugate.
