Preparation of a solid form of gadobenate dimeglumine

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专利权人:

BRACCO IMAGING S.P.A.

发明人:

Roberta Mazzon,Roberta Fretta,Pier Lucio Anelli

申请号：

US15321176

公开号：

US10519171B2

申请日:

2015.07.20

申请国别(地区):

US

年份:

2019

代理人:

摘要：

The present invention relates to a process for the preparation of a solid form of the gadobenate dimeglumine compound that comprises obtaining a solution of the said compound in a suitable solvent A wherein the amount by weight of the water optionally present in the solution is at most equal to or lower than the amount by weight of the gadobenate dimeglumine comprised in the solution and adding the obtained solution to an organic solvent B, acting as an appropriate antisolvent and favoring the formation of a solid form of the gadobenate dimeglumine that can be collected by filtration.

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