PESCHARD, Olivier,DOUCET, Anne,LE ROUX, Richard,MONDON, Philippe
申请号：
IBIB2015/053737
公开号：
WO2015/181688A1
申请日:
2015.05.21
申请国别(地区):
IB
年份:
2015
代理人:
摘要：
The peptides have the general following formula: X–Pro*–Pro*–Xaa–Y in which: •Xaa is selected from Leucine (Leu, L), Arginine(Arg, R), Lysine (Lys, K), Alanine (Ala, A), Serine (Ser, S), and Aspartic acid (Asp, D)； •At the N terminal end of the peptide, X is selected from H, -CO-R1 and -SO2-R1； •At the C terminal end of the peptide, Y is selected from OH, OR1, NH2, NHR1 and NR1R2；•R1and R2 are, independantly from each other, selected from an alkyle, aryle, aralkyle, alkylaryl, alkoxy and aryloxy group, that can be linear, branched, cyclic, poly- cyclic, non-saturated, hydroxylated, carbonylated, phosphorylated and/or sulfured, and which skeletum can comprise an heteroatom, in particular an O, S and/or N atom； •Pro* correspond to a Proline, ananalogue or derivative thereof； •if X is H then Y is selected from OR1, NH2, NHR1 and NR1R2, and if Y is OH then X is -CO-or -SO2-R1； and •the peptide hypoxanthine-Pro-Pro-Arg being excluded. The invention provides the use of the peptides of above formula I to stimulate the synthesis of the molecules constituting the dermal extracellular matrix, including collagen I and IV and elastin. A cosmetic treatment according to the invention includes anti-aging, anti-wrinkles, improving mechanical properties of the skin, firmness/tone/elasticity/suppelness/flexibility, increasing density and volume of the skin, restructuring effect, fighting stretch marks, improving skin barrier and/or skin hydration.L'invention concerne des peptides de la formule générale suivante : X–Pro*–Pro*–Xaa–Y dans laquelle : • Xaa est choisi parmi la leucine (Leu, L), l'arginine (Arg, R), la lysine (Lys, K), l'alanine (Ala, A), la sérine (Ser, S) et l'acide aspartique (Asp, D) ； • à l'extrémité N-terminale du peptide, X est choisi parmi H, -CO-R1 et -SO2-R1 ； • à l'extrémité C-terminale du peptide, Y est choisi parmi OH, OR1, NH2, NHR1 et NR1R2 ； • R1 et R2 sont choisis, indépendamment l'un de l'autre, parmi un groupe alkyle, aryle, aralkyle, alkylaryle, alcoxy
