UNIVERSITY OF SEOUL INDUSTRY COOPERATION FOUNDATION.
发明人:
CHOI, JIN HEEKR,최진희,KIM, JEONG RAEKR,김정래,KIM, HEE JINKR,김희진,KIM, MIN AKR,김민아
申请号：
KR1020150059193
公开号：
KR1020160127587A
申请日:
2015.04.27
申请国别(地区):
KR
年份:
2016
代理人:
摘要：
The present invention relates to a high-throughput mammalian reproductive or developmental toxicity screening method, and a high-throughput mammalian reproductive or developmental toxicity screening system. A high-throughput mammalian reproductive or developmental toxicity screening method according to an exemplary embodiment of the present invention comprises: providing reproductive or developmental toxicity value database of C. elegans for mammalian toxicity positive control group material and negative control group material measuring reproductive or developmental toxicity values of C. elegans for test materials and comparing the measured reproductive or developmental toxicity values with database to determine if the test materials are reproductive or developmental toxicity positive materials. A high-throughput mammalian reproductive or developmental toxicity screening method according to an exemplary embodiment of the present invention is capable of easily predicting mammalian toxicities of the test materials using C. elegans, a non-mammalian model which is low cost and is capable of promptly seeing test results. Therefore, a high-throughput mammalian reproductive or developmental toxicity screening method according to an exemplary embodiment of the present invention is capable of effectively solving ethical problems and economical problems including cost and time of the toxicity screening method.COPYRIGHT KIPO 2016본 발명은 고속 대량 생식 또는 발생 독성 스크리닝 방법 및 시스템에 관한 것이다. 본 발명의 한 실시예에 따른 고속 대량 생식 또는 발생 독성 스크리닝 방법은 포유류 독성 양성 대조군 물질과 음성 대조군 물질의 C. elegans생식 또는 발달 독성치 데이터베이스를 제공하고, 테스트 물질에 대한 C. elegans의 생식 또는 발달 독성치를 측정하고, 생식 또는 발달 독성치를 상기 데이터베이스와 비교하여 상기 테스트 물질이 생식 독성 또는 발달 독성 양성 물질인지 여부를 판단한다.
