A device for in vivo analysis includes: a reaction chamber to store a detecting reagent able to react with a sample collected in vivo and optionally a labeled-substance chamber to store a labeled substance able to bind to at least a portion of a compound resulting from a reaction of the detecting reagent and the sample. The in-vivo imaging device, typically an autonomous capsule, may have a housing, the housing comprising a window an illumination source located within the housing to illuminate a body lumen through the window an imager to receive light reflected from the body lumen through the window and a transmitter to transmit image data to a receiving system. The window is coated with liposomes containing a marker such that the imager may acquire images which include the marking.
