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Thérapies immunes humaines utilisant un agoniste CD27 seuls ou en combinaison avec d'autres modulateurs immunitaires
专利权人:
UNIVERSITY OF SOUTHAMPTON
发明人:
申请号:
EP13185830.0
公开号:
EP2698382A1
申请日:
2007.10.18
申请国别(地区):
EP
年份:
2014
代理人:
摘要:
Methods of inducing T cell proliferation and expansion in vivo for treating conditions wherein antigen-specific T cell immune response are therapeutically desirable such as cancer, infection, inflammation, allergy and autoimmunity and for enhancing the efficacy of vaccines are provided. These methods comprise the administration of at least one CD27 agonist, preferably an agonistic CD27 antibody, alone or in association with another moiety such as immune stimulant or immune modulator such as an anti-CD40, OX-40, 4- IBB, or CTLA-4 antibody or an agent that depletes regulatory cells, or a cytokine. These mono and combination therapies may also optionally include the administration of a desired antigen such as a tumor antigen, an allergen, an autoantigen, or an antigen specific to an infectious agent or pathogen against which a T cell response (often CD8+) is desirably elicited.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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