血栓性血小板減少性紫斑病のモデルおよびその使用方法
- 专利权人:
- 发明人:
- 申请号：
- JP20110533425
- 公开号：
- JP5749649(B2)
- 申请日:
- 2009.10.27
- 申请国别(地区):
- 日本
- 年份:
- 2015
- 代理人:
- 摘要：
The invention relates to the development of an animal model for testing various agents in the treatment of a clotting disorder. More specifically, the invention relates to the use of ultra-large molecular weight multimers of von Willebrand factor (VWF) in various mouse strains to induce thrombotic thrombocytopenic purpura (TTP)-like symptoms for the development of a mouse model of TTP. The invention also provides methods for generating such animal disease models and screening methods for identifying biologically active compounds which are effective in the treatment of TTP.
- 来源网站：
- 中国工程科技知识中心
