Barbara Pui Chan,Hoi Ling Wong,Mei Yi Wong,Godfrey Chi-Fung Chan,Zhen Fan Yang
申请号：
US13159835
公开号：
US09096831B2
申请日:
2011.06.14
申请国别(地区):
US
年份:
2015
代理人:
摘要：
A method is provided to functionally select cells with enhanced characteristics relevant to cell engraftment, including both spontaneous migration and directional migration towards specific chemo-attractants. The cells are preferably undifferentiated cells, such as mesenchymal stem cells. The method involves entrapping or encapsulating the cells in a biomaterial barrier, optionally inducing cell migration, and selecting cells that migrated through the barrier. The cells selected by this method have better migratory activities and enhanced in vivo engraftment to injured tissues when they are supplemented systemically.
