DIXIT, SURJIT BHIMARAO,UROSEV, DUNJA,D'ANGELO, IGOR EDMONDO PAOLO,NG, GORDON YIU KON
申请号：
CA2878587
公开号：
CA2878587A1
申请日:
2013.07.23
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
Disclosed is an isolated immunoglobulin construct comprising a first monomeric polypeptide comprising a first single chain Fv polypeptide connected to a first constant domain polypeptide； and a second monomeric polypeptide comprising a second single chain Fv polypeptide, connected to a second constant domain polypeptide； each said constant domain polypeptide comprising at least one each of a CL domain, a CH1 domain, a CH2 domain and a CH3 domain or fragments, variants or derivatives thereof； and wherein said first and second constant domain polypeptide form a Fc region.
