用於疫苗中之登革熱病毒嵌合式建構物的組成物及方法农业专利-农业专业知识服务系统

专利权人:: INVIRAGEN, INC.;THE GOVERNMENT OF THE UNITED STATES OF AMERICA ASREPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF

发明人:: STINCHCOMB, DAN T.,史汀奇康柏　丹Ｔ,HUANG, CLAIRE Y.,黄　克莱尔Ｙ,黃　克萊爾Ｙ,KINNEY, RICHARD M.,肯尼　理查Ｍ,LIVENGOOD, JILL A.,利文葛德　吉尔Ａ,利文葛德　吉爾Ａ,史汀奇康柏丹T,黄克莱尔Y,黃克萊爾Y,肯尼理查M,利文葛德吉尔A,利文葛德吉爾A

摘要：: Embodiments herein report compositions, uses and manufacturing of dengue virus constructs and live attenuated dengue viruses. Some embodiments concern a composition that includes, but is not limited to, a tetravalent dengue virus composition. In certain embodiments, compositions can include constructs of one or more serotypes of dengue virus, such as dengue-1 (DEN-1) virus, dengue-2 (DEN-2) virus, dengue-3 (DEN-3) or dengue-4 (DEN-4) virus constructs. In other embodiments, constructs disclosed herein can be combined in a composition to generate a vaccine against more one or more dengue virus constructs that may or may not be subsequently passaged in mammalian cells.此處實施例實證登革熱病毒建構物及活減毒登革熱病毒之組成物、用途及製造。若干實施例係有關於一種組成物包括但非限制性，四價登革熱病毒組成物。於某些實施例中，組成物可包括一或多個登革熱病毒血清型之建構物，諸如登革熱-1(DEN-1)病毒、登革熱-2(DEN-2)病毒、登革熱-3(DEN-3)病毒、及登革熱-4(DEN-4)病毒建構物。於其它實施例中，如此處揭示的建構物可組合於一組成物以產生對抗多於一種或多種登革熱病毒建構物之疫苗，該建構物可以或可不接續地於哺乳動物細胞內繼代培養。